The blood transfusion was invented after three years of research, Luis Agote in 1914 invented a system to keep the blood without clots, even direct transfusion existed for many years before, it was not possible to conserve blood, it was necessary to pass it directly and immediately from one patient to the other. I never patented his invention, but he spread it immediately. Luis Agote (Buenos Aires, September 22, 1868 - Turdera (Buenos Aires), November 12, 1954), Argentine physician and researcher. The doctor Luis Agote, was the first to perform in the world indirect blood transfusions without the blood coagulating in the container that contained it. He also had a role in the politics of the Province of Buenos Aires during the second decade of the twentieth century in 1914. Biography He made his secondary studies at the National Central School (current National College of Buenos Aires) of his hometown. He entered the Faculty of Medicine of the University of Buenos Aires in 1887, where he graduated as a doctor in 1893 with a thesis on suppurative hepatitis. In 1894 he became Secretary of the National Department of Hygiene and in 1895 he took charge of the direction of the lazaretto of the island Martín García. In 1899 he was appointed Physician of the Sala de Hospital Rawson (city of Buenos Aires), where he was later Head of the Chamber. In 1905 he was appointed Alternate Professor of the Faculty of Medicine and in 1915 Professor of Medical Clinic of the University of Buenos Aires, chair of the latter which he held until his resignation in 1929. In 1914 he founded the Model Institute of Medical Clinic of Rawson Hospital, where he carried out a vast program of research, professional education and assistance to the sick. That's where he developed and put into practice the method of preserving blood for transfusions by the addition of sodium citrate. Sepulcher of Dr Agote in Recoleta. Agote's vocation for service was not exhausted in medicine. He acted from young in the Argentine political life. He was elected Deputy and Senator in the province of Buenos Aires; appointed Municipal Commissioner of the Party of General San Martín in 1912 and twice National Deputy (1910 and 1916). From this last bank he was author of laws such as the creation of the National University of the Coast, the annexation of the National College of Buenos Aires to the University of Buenos Aires and the creation of the National Board of Abandoned Children and Offenders. He wrote on medical and health, literary and historical subjects, some of his works being a new simple method for blood transfusions (1914); Study of public hygiene in the Argentine Republic, memory of the National Department of Hygiene; The gastric and duodenal ulcer in the Argentine Republic (1916); Biliary lithiasis (1916); Illusion and reality (poem); Augustus and Cleopatra; Nero, his and his time. A psychopathology of the Roman emperor (1912); My memories. Much of his medical work was published in the Annals of the Model Institute of Medical Clinic. Throughout his life he received multiple distinctions, among others: Honorary Professor of the National College and the University of Buenos Aires; Honorary Member of the National Academy of Medicine; Honorary President of the National Academy of Fine Arts, the Children's Tutelage Association and the 8th National Congress of Medicine. The Republic of Chile distinguished him, in 1916, with the Order of Merit. Agote died in the city of Turdera (Calle Pretti 311) on November 12, 1954, exactly three days after the 40th anniversary of the first blood transfusion that had him as the main protagonist. To honor his contribution to Medicine, a street was named after him, a National School of Commerce, the Model Institute of Medical Clinic, the National Institute for the Protection of Minors, the Hemotherapy Center of the Hospital de Clínicas - all of the city of Buenos Aires- as well as primary schools, hemotherapy centers and blood banks throughout the country. His remains rest in the Recoleta cemetery. The transfusion of blood. Main article: Blood transfusion. Since ancient times it was believed that blood was a factor of health and strength, and in some cultures was given to drink human blood to invigorate or revive the sick. There is evidence that in Imperial Rome the blood of the gladiators wounded in the sand was used for the healing of epilepsy. The idea of the blood transfusion already existed in 1056, when Jerónimo Cardano de Basilea, in his work De Rerum Varietate, suggested replacing that of the delinquents.